Intraperitoneal Acute Toxicity of Aluminum Hydroxide Nanoparticle as an Adjuvant Vaccine Candidate in Mice
نویسندگان
چکیده
منابع مشابه
Potentiation of human papilloma vaccine candidate using naloxone/alum mixture as an adjuvant: increasing immunogenicity of HPV-16E7d vaccine
Objective(s): Many types of human papillomaviruses (HPVs) have been identified, with some leading to cancer and others to skin lesions such as anogenital warts. Studies have demonstrated an association between oncogenic HPV and cervical cancer and many researchers have focused on therapeutic vaccines development. At present, the modulatory effect of opioids on the innate and acquired immune sys...
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Mice immunized with a subcutaneous protocol combining killed para sites and aluminum hydroxide gel exhibited significant resistance against subsequent challenge with Leishmania donovani promastigotes. Protec tion was greatest using 25 mg of aluminum hydroxide per injection. Resis tance elicited by this killed parasite and aluminum hydroxide protocol was as effective on day 14 as that provide...
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Current vaccination strategies for commercial poultry using live attenuated and inactivated Newcastle disease (ND) vaccines have some limitation and difficulties, and new vaccines with distinct features are needed. Recently, in ovo vaccination technology is concerned as a safe, efficacious, and convenient method. Common ND vaccines used in chickens cannot be employed in ovo due to embryo toxici...
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BACKGROUND Toll-like receptor (TLR) agonists reportedly have potent antiviral and antitumor activities and may be a new kind of adjuvant for enhancing immune efficacy. Resiquimod (R848) is an imidazoquinoline compound with potent antiviral activity and functions through the TLR7/TLR8 MyD88-dependent signaling pathway. Polyinosinic-polycytidylic acid [poly(I:C)] is a synthetic analog of double-s...
متن کاملEffect of aluminum hydroxide adjuvant and formaldehyde in the formulation of rPA anthrax vaccine.
The serological response and efficacy of Bacillus anthracis recombinant protective antigen (rPA) vaccines formulated with aluminum hydroxide adjuvant, either with or without formaldehyde, were evaluated in rabbits. Rabbits that had been injected with a single dose of 25 microg of rPA adsorbed to 500 microg of aluminum in aluminum hydroxide gel (Alhydrogel) had a significantly higher quantitativ...
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ژورنال
عنوان ژورنال: Journal of Pharmacology and Toxicology
سال: 2019
ISSN: 1816-496X
DOI: 10.3923/jpt.2020.22.35